![]() These data indicate hyperventilation causes no adverse effects, to include inflammation and tissue damage, and that acute overventilation, as could be seen in the prehospital phase of trauma care, does not produce evidence of adverse effects on the lungs following moderate hemorrhage. On pathological review, severity and distribution of lung edema or other gross pathologies were not significantly different between groups. Blood markers of tissue damage and plasma cytokines were not statistically different between groups with the exception of a transient increase in IL-1β all values returned to baseline by 24 h. No level of manual ventilation had any significant impact on hemodynamic variables. Pigs then regained consciousness and recovered for 24 h, followed by euthanasia and collection of blood and tissue samples. min volume, ∼750 mL tidal volume, 20 breaths/minute), or 5) mechanical ventilation.min volume, ∼750 mL tidal volume, 12 breaths/minute), 4) maximum hyperventilation (15 L.min volume, ∼400 mL tidal volume, 12 breaths/minute), 3) bag hyperventilation (9 L.Female Yorkshire pigs (40–50 kg, n = 10/group) were anesthetized, instrumented for hemodynamic measurements and blood sampling, and underwent a 25% controlled hemorrhage followed by 1 h of 1) spontaneous breathing, 2) “normal” bag ventilation (4.8 L We hypothesized that acute hyperventilation, as might inadvertently be performed in prehospital settings, would elevate systemic inflammation and cause lung damage. ![]() ![]() Prolonged mechanical ventilation results in overventilation-induced lung barotrauma, but few studies have examined the consequence of acute (1 h or less) overventilation. Airway management is important in trauma and critically ill patients.
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